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Continuous Buffer Management System: Large-Scale Buffer Preparation

Zuwei Jin, PhD
Continuous Buffer Management System: Large-Scale Buffer Preparation

Content originally published in Pharmaceutical Engineering® May/June 2024, Volume 44, Number 3.

Although traditional tank farm systems have long been the cornerstone of buffer preparation, they face challenges that have grown with the expansion of processing scale in the industry.  This article explores the concept of the continuous buffer management system (CBMS) as an alternative to traditional buffer tank farm methods. We analyze the historical progression of buffer preparation, highlight the advantages and challenges of the CBMS, and present an overview of its hardware components, system design, and process control strategies to demonstrate the viability of the CBMS as a robust and cost-effective solution for biopharmaceutical buffer management at production scale.

About Lisure Technology Co.


LisureLisure Technology Co. is an US subsidiary of Lisure Science (Suzhou) Co., China. Lisure provides total DSP solutions, exemplified by the 15,000 L/hr system and 2-meter diameter chromatography column and innovative solutions such as CBMS and RTF, yielding remarkable economic and operational benefits. Lisure stands out with unparalleled process expertise and engineering capabilities, covering hardware fabrication, component machining, flow system design, process control, and S88 batch operation management. Operating within a GAMP framework, Lisure brings extensive experience in executing full GAMP projects for customers in cGMP regulated industries.

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